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Buy Remifentanil 5mg/ml Online: Formulations and Dosage Information

Remifentanil is available in the following formulation:

Remifentanil 5mg Powder for Solution: For intravenous administration after reconstitution

Remifentanil is an ultra-short-acting synthetic opioid analgesic used for anesthesia and procedural sedation. It is unique among opioids due to its ester linkage, which allows for rapid metabolism by non-specific blood and tissue esterases, resulting in an extremely short context-sensitive half-time regardless of infusion duration.

Remifentanil is primarily used for:

Induction and maintenance of general anesthesia
Analgesia during monitored anesthesia care
Procedural sedation
Supplementation of local or regional anesthesia
Intensive care sedation for mechanically ventilated patients

Dosing is individualized based on the specific medical indication, patient characteristics, and concurrent medications. Typical dosage ranges include:

For induction of anesthesia: 0.5-1 mcg/kg/min IV infusion with or without an initial bolus of 1 mcg/kg
For maintenance of anesthesia: 0.05-2 mcg/kg/min IV infusion, titrated to effect
For procedural sedation: 0.025-0.2 mcg/kg/min IV infusion, with or without initial bolus of 0.5-1 mcg/kg
For intensive care sedation: 0.1-0.15 mcg/kg/min IV infusion, titrated to effect

Important Safety Information

Remifentanil is a Schedule II controlled substance with potential for abuse and dependence. It should be administered by or under the supervision of healthcare professionals familiar with its use, specifically anesthesiologists or those trained in anesthesia administration.

Due to its potent respiratory depressant effects, Remifentanil should only be administered in settings where personnel are trained in airway management and resuscitation equipment is immediately available. Continuous monitoring of vital signs, including pulse oximetry, capnography, and blood pressure, is essential during administration.

Potential Side Effects

Common side effects include dose-dependent respiratory depression, bradycardia, hypotension, muscle rigidity (particularly with rapid administration), nausea, and vomiting. Serious adverse effects requiring immediate intervention include severe respiratory depression, chest wall rigidity, and allergic reactions.

Remifentanil should be used with caution in patients with respiratory impairment, bradyarrhythmias, hypovolemia, and in elderly or debilitated patients. Due to its rapid offset of action, transition to longer-acting analgesics should be considered before discontinuation to prevent acute pain upon emergence.

For more information about anesthetic medications and opioid safety, please visit these authoritative resources:

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Remifentanil is a synthetic opioid analgesic with the following characteristics:

Chemical Name: 3-[4-methoxycarbonyl-4-[(1-oxopropyl)phenylamino]-1-piperidine]propanoic acid, methyl ester, hydrochloride
Mechanism of Action: Selective mu-opioid receptor agonist
Onset of Action: 1-1.5 minutes when administered intravenously
Duration of Action: 5-10 minutes after discontinuation of infusion
Metabolism: Rapid hydrolysis by non-specific blood and tissue esterases
Elimination Half-life: 3-10 minutes
Context-Sensitive Half-time: 3-4 minutes, regardless of infusion duration
Potency Comparison: Approximately 20-30 times more potent than alfentanil

Remifentanil offers several unique clinical advantages:

Ultra-short duration of action allowing for precise titration and rapid recovery
Consistent context-sensitive half-time regardless of infusion duration
Metabolism independent of liver and kidney function
Minimal drug accumulation even with prolonged infusions
Rapid offset of effect allowing for quick assessment of neurological status
Predictable pharmacokinetic profile across patient populations
Ideal for procedures requiring intense analgesia with rapid recovery

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“As an anesthesiologist, I rely on Remifentanil for cases requiring precise control of analgesia with rapid emergence. Having a dependable source that ensures proper storage and handling of this critical medication is essential for our practice.” – Dr. James K., MD, Anesthesiology

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