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Hydrocodone is a full opioid agonist with relative selectivity for the mu-opioid (μ) receptor, although it can interact
with other opioid receptors at higher doses. The principal therapeutic action of hydrocodone is analgesia. Like all
full opioid agonists, there is no ceiling effect for analgesia with hydrocodone. Clinically, the dosage is titrated to
provide adequate analgesia and may be limited by adverse reactions, including respiratory and CNS depression.
The precise mechanism of the analgesic action is unknown. However, specific CNS opioid receptors for
endogenous compounds with opioid-like activity have been identified throughout the brain and spinal cord and are
thought to play a role in the analgesic effects of this drug. The precise mechanism of the analgesic properties of
acetaminophen is not established but is thought to involve central actions.
Pharmacodynamics Buy Hydrocodone 10-325mg Online
Effects on the Central Nervous System
The principal therapeutic action of hydrocodone is analgesia. Hydrocodone produces respiratory depression by
direct action on brain stem respiratory centers. The respiratory depression involves a reduction in the
responsiveness of the brain stem respiratory centers to both increases in carbon dioxide tension and electrical
stimulation.

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Hydrocodone causes miosis, even in total darkness. Pinpoint pupils are a sign of opioid overdose but are not
pathognomonic (e.g., pontine lesions of hemorrhagic or ischemic origins may produce similar findings). Marked
mydriasis rather than miosis may be seen due to hypoxia in overdose situations.
Therapeutic doses of acetaminophen have negligible effects on the cardiovascular or respiratory systems; however,
toxic doses may cause circulatory failure and rapid, shallow breathing.
Effects on the Gastrointestinal Tract and Other Smooth Muscle
Hydrocodone causes a reduction in motility associated with an increase in smooth muscle tone in the antrum of the
stomach and duodenum. Digestion of food in the small intestine is delayed and propulsive contractions are
decreased. Propulsive peristaltic waves in the colon are decreased, while tone may be increased to the point of
spasm, resulting in constipation. Other opioid-induced effects may include a reduction in biliary and pancreatic
secretions, spasm of the sphincter of Oddi, and transient elevations in serum amylase.
Effects on the Cardiovascular System. Buy Hydrocodone 10-325mg Online
Hydrocodone produces peripheral vasodilation which may result in orthostatic hypotension or syncope.
Manifestations of histamine release and/or peripheral vasodilation may include pruritus, flushing, red eyes,
sweating, and/or orthostatic hypotension.

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