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Oxymorphone is available in multiple formulations to suit different pain management needs:

• Immediate-Release Tablets: Available in 5mg and 10mg strengths, typically taken every 4-6 hours for quick pain relief
• Extended-Release Tablets (Opana ER): Available in 5mg, 7.5mg, 10mg, 15mg, 20mg, 30mg, and 40mg strengths, taken every 12 hours for around-the-clock pain control
• Injectable Solution: Available in 1mg/ml concentration for severe pain requiring rapid onset of relief

Dosing is highly individualized based on pain severity, previous opioid experience, and patient characteristics. For opioid-naïve patients, treatment typically begins with the lowest effective dose and is adjusted based on response. Patients with prior opioid experience may require higher initial doses. Extended-release formulations are not appropriate for as-needed pain relief and should only be used for around-the-clock pain management.

Oxymorphone is approximately 3 times more potent than oral morphine on a milligram-per-milligram basis, requiring careful dosing and conversion when switching from other opioids.

Important Safety Information

Oxymorphone is a Schedule II controlled substance with high potential for abuse and dependence. Always use as directed by your healthcare provider. Do not combine with alcohol, benzodiazepines, or other central nervous system depressants. Store in a secure location away from children and pets. Dispose of unused medication properly according to local regulations.

Oxymorphone may cause respiratory depression, which can be life-threatening, particularly in opioid-naïve patients or when taken in excessive doses. Patients with respiratory conditions such as COPD or asthma should use oxymorphone with extreme caution and under close medical supervision.

Potential Side Effects

Common side effects may include drowsiness, dizziness, sedation, nausea, vomiting, constipation, and sweating. Serious side effects requiring immediate medical attention include difficulty breathing, severe drowsiness, confusion, or allergic reactions. Consult with a healthcare professional before use if you have respiratory conditions, liver or kidney disease, or a history of substance abuse.

For more information about opioid medications and pain management, please visit these authoritative resources:

• CDC Guidelines for Opioid Use
• FDA Information on Opioid Medications
• MedlinePlus Oxymorphone Information

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Oxymorphone is a semi-synthetic opioid derived from thebaine with the following characteristics:

• Primary Mechanism: Binds with high affinity to mu-opioid receptors in the brain, spinal cord, and peripheral tissues, changing the perception of and emotional response to pain
• Potency: Approximately 3 times more potent than oral morphine on a milligram-per-milligram basis
• Onset of Action: Rapid onset (15-30 minutes for oral immediate-release formulations, 5-10 minutes for injectable)
• Duration of Action: 4-6 hours for immediate-release formulations, 12 hours for extended-release
• Metabolism: Primarily metabolized in the liver via glucuronidation

This medication is particularly effective for:

• Moderate to severe acute pain
• Chronic cancer pain
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Oxymorphone offers several advantages over other opioids, including high potency, good oral bioavailability (despite first-pass metabolism), and minimal production of active metabolites. This last feature makes it potentially suitable for patients with renal impairment, as there is less risk of metabolite accumulation compared to some other opioids. Its multiple formulations allow for tailored pain management approaches based on individual patient needs and circumstances.

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