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Butomidor(Butorphanol) 10mg/ml Injection

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Butorphanol is available in the following formulations:

Butorphanol 2mg/ml Injectable Solution: For intramuscular or intravenous administration
Butorphanol 10mg/ml Nasal Spray: For intranasal administration

Butorphanol is a synthetic opioid analgesic with mixed agonist-antagonist properties. It acts as an agonist at kappa opioid receptors and a partial antagonist at mu opioid receptors, providing effective analgesia while limiting some of the adverse effects associated with pure mu agonists.

Butorphanol is primarily used for:

Management of moderate to severe pain
Treatment of migraine headaches (nasal spray)
Preoperative or preanesthetic medication
Supplement to balanced anesthesia
Labor analgesia

Dosing is individualized based on the specific medical indication, patient characteristics, and concurrent medications. Typical dosage ranges include:

For injectable form: 1mg to 4mg every 3-4 hours as needed, not to exceed 24mg daily
For nasal spray: 1mg (1 spray in one nostril) every 3-4 hours as needed, not to exceed 8 sprays per day

Important Safety Information

Butorphanol is a Schedule IV controlled substance with potential for dependence, though this risk is lower compared to pure mu agonists. It should be administered by or under the supervision of healthcare professionals familiar with its use.

Due to its partial antagonist properties, Butorphanol may precipitate withdrawal symptoms in patients physically dependent on pure opioid agonists. It should not be administered to patients who are dependent on opioids or are in opioid withdrawal.

Potential Side Effects

Common side effects include sedation, dizziness, nausea, vomiting, and sweating. Serious adverse effects requiring immediate intervention include respiratory depression, hypotension, and allergic reactions. Butorphanol may cause psychotomimetic effects in some patients, including hallucinations, dysphoria, and confusion.

Butorphanol should be used with caution in patients with respiratory impairment, head injury, increased intracranial pressure, impaired hepatic or renal function, and in elderly or debilitated patients.

For more information about pain management medications and opioid safety, please visit these authoritative resources:

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Butorphanol is a synthetic opioid analgesic with the following characteristics:

Chemical Name: 17-(cyclobutylmethyl)morphinan-3,14-diol tartrate
Mechanism of Action: Kappa opioid receptor agonist and partial mu opioid receptor antagonist
Onset of Action: 10-15 minutes when administered intramuscularly, 1-2 minutes when administered intravenously, 15 minutes when administered intranasally
Duration of Action: 3-4 hours
Metabolism: Primarily hepatic
Elimination Half-life: 2.5-4 hours
Potency Comparison: Approximately 5-7 times the potency of morphine for analgesia

Butorphanol offers several clinical advantages in specific scenarios:

Less respiratory depression than pure mu agonists at equianalgesic doses
Lower potential for physical dependence compared to Schedule II opioids
Minimal effect on cardiovascular parameters at therapeutic doses
Available in both injectable and intranasal formulations for versatile administration
Classified as Schedule IV controlled substance, indicating lower abuse potential
Particularly effective for migraine headaches via the intranasal route
May cause less constipation than morphine and other pure mu agonists

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