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  • Ketamine Nasal Spray 50mg/ml: Standard concentration for depression treatment
  • Ketamine Nasal Spray 100mg/ml: Higher concentration for treatment-resistant depression and chronic pain
  • Esketamine Nasal Spray (S-ketamine): FDA-approved formulation specifically for treatment-resistant depression

The typical dosing protocol for depression involves 1-2 sprays per nostril (depending on concentration), administered under medical supervision initially, with frequency determined by clinical response. For chronic pain management, dosing regimens are highly individualized based on pain severity, previous medication history, and individual response.

Dosing should always be supervised by a healthcare provider experienced in ketamine therapy, particularly during initial treatment phases. Many patients begin with twice-weekly administrations for 1-4 weeks, followed by once-weekly or less frequent maintenance dosing based on response.

Important Safety Information

Ketamine is a Schedule III controlled substance with potential for abuse. Always use as directed by your healthcare provider. Do not drive or operate machinery for at least 24 hours after administration. Monitoring is required during and after initial doses due to potential for dissociative effects, blood pressure changes, and sedation. Not recommended for patients with uncontrolled hypertension, aneurysmal vascular disease, intracerebral hemorrhage, or hypersensitivity to ketamine.

Ketamine nasal spray should be used as part of a comprehensive treatment program for depression or pain management, including psychological support, therapy, and appropriate follow-up. It is not intended as a first-line treatment but rather for patients who have not responded adequately to conventional therapies.

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Common side effects may include dissociation, dizziness, nausea, sedation, vertigo, decreased sensitivity, anxiety, increased blood pressure, vomiting, and feeling drunk. Most side effects are transient and resolve within 1-2 hours after administration. Serious side effects requiring immediate medical attention include severe increases in blood pressure, respiratory depression, or allergic reactions. Consult with a healthcare professional before use if you have cardiovascular conditions, respiratory issues, liver problems, substance abuse history, or psychosis.

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  • Primary Mechanism: NMDA receptor antagonist that modulates glutamate, the primary excitatory neurotransmitter in the brain
  • Secondary Mechanisms: Effects on AMPA receptors, opioid receptors, and monoaminergic systems contributing to antidepressant and analgesic effects
  • Onset of Action: Rapid, typically within 10-40 minutes for intranasal administration
  • Duration of Antidepressant Effect: Variable, typically 3-14 days following a single administration
  • Bioavailability: Approximately 25-50% for intranasal administration, avoiding first-pass metabolism

This medication is particularly effective for:

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  • Fibromyalgia
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Ketamine offers several advantages in specific clinical scenarios, including its rapid onset of action (hours to days versus weeks for conventional antidepressants), efficacy in treatment-resistant cases, and novel mechanism of action that addresses glutamatergic dysfunction rather than focusing solely on monoamine neurotransmitters. The intranasal route provides convenient administration with faster absorption compared to oral formulations while avoiding the need for intravenous access.

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“After years of treatment-resistant depression and trying numerous medications, ketamine nasal spray has been life-changing. Within hours of my first dose, I felt a lifting of the heaviness that had been with me for years. The overnight delivery option meant I could start treatment quickly after my doctor’s recommendation.” – Emily R.

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Ketamine 50 mg Intranasal SprayKetamine 50 mg (Intranasal)
Original price was: $15.00.Current price is: $10.00.