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Dextropropoxyphene is available in the following formulation:
- Dextropropoxyphene 65mg Capsules: For oral administration
Dextropropoxyphene (previously marketed as Darvon) is a mild opioid analgesic that works by binding to opioid receptors in the brain and spinal cord, changing how your body feels and responds to pain. It is structurally related to methadone but has significantly less analgesic potency.
Dextropropoxyphene is primarily used for:
- Relief of mild to moderate pain
- Short-term pain management
- Adjunct therapy in combination with other analgesics
Dosing is individualized based on the specific medical indication, patient characteristics, and concurrent medications. Typical dosage ranges include:
- For pain relief: 65mg every 4 hours as needed, not to exceed 390mg in 24 hours
- For elderly patients: Reduced dosages, typically starting at 32.5mg every 4 hours
Important Safety Information
Dextropropoxyphene is a Schedule IV controlled substance with potential for abuse and dependence. It should be used under the supervision of healthcare professionals familiar with opioid medications.
Important note: Dextropropoxyphene has been withdrawn from several markets including the United States, European Union, and other countries due to concerns about cardiac toxicity and fatal overdoses. However, it remains available in certain international markets for specific medical uses under strict supervision.
Potential Side Effects
Common side effects include drowsiness, dizziness, sedation, nausea, vomiting, constipation, and headache. Serious adverse effects requiring immediate medical attention include respiratory depression, cardiac arrhythmias (particularly QT prolongation), confusion, severe drowsiness, and allergic reactions.
Dextropropoxyphene should be used with caution in patients with respiratory impairment, cardiac conditions, liver or kidney dysfunction, and in elderly or debilitated patients. It has significant drug interactions, particularly with other CNS depressants, monoamine oxidase inhibitors, and medications that affect cardiac conduction.
For more information about pain management medications and opioid safety, please visit these authoritative resources:
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Dextropropoxyphene is an opioid analgesic with the following characteristics:
- Chemical Name: (+)-4-dimethylamino-3-methyl-1,2-diphenyl-2-butanol propionate
- Mechanism of Action: Mu-opioid receptor agonist
- Onset of Action: 30-60 minutes when administered orally
- Duration of Action: 4-6 hours
- Metabolism: Hepatic, primarily via CYP3A4
- Elimination Half-life: 6-12 hours (parent compound), 30-36 hours (active metabolite norpropoxyphene)
- Potency Comparison: Approximately 1/2 to 2/3 the potency of codeine
Dextropropoxyphene has several clinical considerations:
- Effective for mild to moderate pain relief
- Metabolized to norpropoxyphene, which has cardiac effects including QT prolongation
- Lower abuse potential compared to stronger opioids
- Available primarily as oral capsules
- Can be combined with non-opioid analgesics for enhanced pain relief
- Has a narrow therapeutic index, particularly in overdose situations
- Requires careful monitoring in patients with cardiac conditions
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