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Ozempic is available in the following formulation:
- Ozempic 1mg Injection Pen: For subcutaneous administration, maximum therapeutic dose
Ozempic (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist that works by increasing insulin secretion when blood sugar is high, decreasing glucagon secretion, slowing gastric emptying, and reducing appetite, leading to improved glycemic control and weight loss.
Ozempic 1mg is primarily used for:
- Management of type 2 diabetes mellitus as an adjunct to diet and exercise
- Reduction of the risk of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease
- Weight management in patients with obesity or overweight with at least one weight-related comorbidity
- Maximum therapeutic dose for patients requiring additional glycemic control
Dosing information for Ozempic 1mg:
- Maximum therapeutic dose: 1mg once weekly
- Prior titration: After at least 4 weeks on 0.5mg once weekly
- Administration: Subcutaneous injection in the abdomen, thigh, or upper arm
- Timing: Can be administered any day of the week, with or without meals
- Dose adjustment: No further dose escalation beyond 1mg for diabetes (2mg dose is available for weight management)
Important Safety Information
Ozempic is a prescription medication that requires proper medical supervision. It is not recommended for use in patients with a personal or family history of medullary thyroid carcinoma or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Ozempic should be stored in the refrigerator (36°F to 46°F or 2°C to 8°C) before first use. After first use, the pen can be stored at room temperature (below 86°F or 30°C) or in the refrigerator for up to 56 days (8 weeks).
Potential Side Effects
Common side effects include nausea, vomiting, diarrhea, abdominal pain, and constipation. These gastrointestinal effects typically decrease over time but may be more pronounced at the 1mg dose. Serious adverse effects requiring immediate medical attention include pancreatitis, diabetic retinopathy complications, hypoglycemia (when used with insulin or insulin secretagogues), acute kidney injury, and allergic reactions.
Ozempic should be used with caution in patients with a history of pancreatitis, diabetic retinopathy, and renal impairment. It is not recommended for use during pregnancy or breastfeeding.
For more information about diabetes management and GLP-1 receptor agonists, please visit these authoritative resources:
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Ozempic (semaglutide) 1mg offers superior clinical benefits for patients with type 2 diabetes:
- Enhanced Glycemic Control: In clinical trials, Ozempic 1mg reduced HbA1c by 1.5-1.8% from baseline
- Superior Weight Management: Average weight loss of 5.5-6.5 kg (12.1-14.3 lbs) over 30-52 weeks
- Cardiovascular Benefits: 26% reduction in risk of major adverse cardiovascular events in patients with established cardiovascular disease
- Convenient Dosing: Once-weekly administration improves treatment adherence compared to daily medications
- Low Hypoglycemia Risk: Minimal risk of hypoglycemia when used as monotherapy
The 1mg dose is the maximum therapeutic dose for diabetes management, offering additional glycemic control for patients who do not achieve target HbA1c with the 0.5mg dose. Clinical data shows that approximately 73% of patients achieve target glycemic control (HbA1c <7%) with the 1mg dose.
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