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Codeine Phosphate is available in the following formulation:
- Codeine Phosphate 30mg Tablets: For oral administration
Codeine Phosphate is a mild to moderate opioid analgesic and antitussive (cough suppressant) that works by binding to opioid receptors in the brain and spinal cord, changing how your body feels and responds to pain. It also suppresses the cough reflex by direct action on the cough center in the medulla.
Codeine Phosphate is primarily used for:
- Relief of mild to moderate pain
- Suppression of persistent, non-productive cough
- Management of diarrhea (in certain formulations)
- Adjunct therapy in combination with other analgesics
Dosing is individualized based on the specific medical indication, patient characteristics, and concurrent medications. Typical dosage ranges include:
- For pain relief: 15-60mg every 4-6 hours as needed, not to exceed 240mg in 24 hours
- For cough suppression: 10-20mg every 4-6 hours as needed, not to exceed 120mg in 24 hours
- For elderly patients: Reduced dosages, typically starting at the lower end of the dosage range
Important Safety Information
Codeine Phosphate is a Schedule II controlled substance with potential for abuse and dependence. It should be used under the supervision of healthcare professionals familiar with opioid medications.
Codeine is metabolized to morphine in the liver by the CYP2D6 enzyme. Some individuals are “ultra-rapid metabolizers” and convert codeine to morphine more rapidly and completely than others, which can lead to unexpected side effects including respiratory depression, especially in children.
Potential Side Effects
Common side effects include drowsiness, lightheadedness, dizziness, sedation, shortness of breath, nausea, vomiting, sweating, and constipation. Serious adverse effects requiring immediate medical attention include respiratory depression, confusion, severe drowsiness, and allergic reactions.
Codeine should be used with caution in patients with respiratory impairment, head injuries, increased intracranial pressure, and in elderly or debilitated patients. It should not be used in children under 12 years of age or in children under 18 years of age after tonsillectomy and/or adenoidectomy.
For more information about pain management medications and opioid safety, please visit these authoritative resources:
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Codeine Phosphate is an opioid analgesic with the following characteristics:
- Chemical Name: 7,8-didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol phosphate
- Mechanism of Action: Mu-opioid receptor agonist
- Onset of Action: 30-60 minutes when administered orally
- Duration of Action: 4-6 hours
- Metabolism: Hepatic via CYP2D6 (converted to morphine)
- Elimination Half-life: 2.5-4 hours
- Potency Comparison: Approximately 1/10 the potency of morphine
Codeine Phosphate offers several clinical advantages in specific scenarios:
- Effective for mild to moderate pain relief
- Particularly effective for cough suppression
- Lower incidence of respiratory depression compared to stronger opioids (in normal metabolizers)
- Available in various formulations including tablets, oral solutions, and injections
- Can be combined with non-opioid analgesics for enhanced pain relief
- Step 2 on the WHO analgesic ladder for pain management
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